Table 2 Comparisons of grade 3–4 AEs between the three groups
AmB | L-AmB | ABCD | p value | |||
|---|---|---|---|---|---|---|
(n = 139) | (n = 51) | (n = 15) | AmB vs. L-AmB | AmB vs. ABCD | L-AmB vs. ABCD | |
Total grade 3–4 AEs, n(%) | 50 (36.0) | 9 (17.6) | 10 (66.7) | 0.02 | 0.02 | 0.001 |
Grade 3, n(%) | 32 (23.0) | 7 (13.7) | 2 (13.3) | 0.16 | 0.59 | 1.00 |
Grade 4, n(%) | 18 (12.9) | 2 (3.9) | 8 (53.3) | 0.13 | < 0.001 | < 0.001 |
Grade 3–4 hepatotoxicity, n(%) | 2 (1.4) | 0 (0.0) | 0 (0.0) | 1.00 | 1.00 | / |
Grade 3, n(%) | 2 (1.4) | 0 (0.0) | 0 (0.0) | 1.00 | 1.00 | / |
Grade 4, n(%) | 0 (0.0) | 0 (0.0) | 0 (0.0) | / | / | / |
Grade 3–4 nephrotoxicity, n(%) | 37 (26.6) | 6 (11.8) | 4 (26.7) | 0.03 | 1.00 | 0.31 |
Grade 3, n(%) | 23 (16.5) | 4 (7.8) | 2 (13.3) | 0.20 | 1.00 | 0.89 |
Grade 4, n(%) | 14 (10.1) | 2 (3.9) | 2 (13.3) | 0.29 | 1.00 | 0.47 |
Grade 3–4 hematological toxicity, n(%) | 13 (9.3) | 1 (2.0) | 10 (66.7) | 0.16 | < 0.001 | < 0.001 |
Grade 3, n(%) | 9 (6.5) | 1 (2.0) | 2 (13.3) | 0.38 | 0.65 | 0.25 |
Grade 4, n(%) | 4 (2.9) | 0 (0.0) | 8 (53.3) | 0.57 | 0.001 | < 0.001 |
Grade 3–4 neutropenia, n(%) | 6 (4.3) | 0 (0.0) | 8 (53.3) | 0.19 | 0.008 | < 0.001 |
Grade 3, n(%) | 3 (2.1) | 0 (0.0) | 3 (20) | 0.56 | 0.007 | 0.01 |
Grade 4, n(%) | 3 (2.1) | 0 (0.0) | 5 (33.3) | 0.56 | < 0.001 | < 0.001 |
Grade 3–4 hypohemoglobin, n(%) | 4 (2.9) | 0 (0.0) | 0 (0.0) | 0.57 | 1.00 | / |
Grade 3, n(%) | 4 (2.9) | 0 (0.0) | 0 (0.0) | 0.57 | 1.00 | / |
Grade 4, n(%) | 0 (0.0) | 0 (0.0) | 0 (0.0) | / | / | / |
Grade 3–4 thrombocytopenia, n(%) | 5 (3.6) | 1 (2.0) | 6 (40.0) | 0.92 | < 0.001 | < 0.001 |
Grade 3, n(%) | 4 (2.9) | 1 (2.0) | 2 (13.3) | 1.00 | 0.20 | 0.25 |
Grade 4, n(%) | 1 (0.7) | 0 (0.0) | 4 (26.7) | 1.00 | < 0.001 | 0.002 |