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Table 1 Clinical characteristics of cases with syphilis

From: Epidemic of multiple Treponema pallidum strains in men who have sex with men in Japan: efficient multi-locus sequence typing scheme and indicator biomarkers

  

All cases

Cases that were not accessible for MLST

Fully-typed cases by MLST

P value

Number of cases

 

71

 

51

 

20

  

Median age, yr (IQR)

 

43

(37–49)

41

(34–48)

44

(37–50)

0.37

HIV infection, n (%)

 

69

(97.2)

51

(100)

18

(90.0)

0.08

Stage of syphilis, n (%)

Primary syphilis

7

(9.9)

3

(7.8)

4

(20)

0.09

 

Secondary syphilis

23

(32)

15

(29)

8

(40)

0.41

 

Early Asymptomatic syphilis

35

(49)

28

(54)

7

(35)

0.19

 

Neurosyphilis*

6

(8.5)

3

(5.9)

3

(15)

0.34

 

Unknown

6

(8.5)

5

(9.8)

1

(5%)

0.67

Serum TPLA titer, Median, U/mL (IQR)

 

6571

(2592–15857)

5351

(2325–10774)

14,483

(4054–24596)

0.018

Serum RPR titer, Median, R.U. (IQR)

 

75.7

(34.4 -188.5)

60.9

(27.8 -136.5)

188.7

(59.8 -337.2)

0.0081

CRP, mg/dL (IQR)

 

0.23

(0.09–0.65)

0.14

(0.065–0.33)

1.04

(0.61–1.36)

< 0.0001

  1. MLST, multi-locus sequence typing; TPLA, Treponema pallidum latex agglutination; RPR, Rapid Plasma Reagin; CRP, C-reactive protein * All symptoms were indicative of secondary syphilis and were categorized as such Mann-Whitney test, Fisher’s exact test