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Table 1 Baseline demographic and clinical characteristics of ART-experienced, virologically suppressed PWH switching to DTG/3TC, BIC/FTC/TAF, or a DTG 3DR between 01MAY2019 and 31OCT2020 (N = 8,037)

From: Virologically suppressed switch to Dolutegravir/Lamivudine 2-Drug regimen versus switch to commonly prescribed 3-Drug regimens in the United States

 

DTG/3TCa

(N = 1,450)

BIC/FTC/TAFb

(N = 5,691)

DTG 3DRc

(N = 896)

Age, Median (IQR)

45 (34, 55)

43 (32, 54)

43 (32, 53)

Sex, n (%)

   

 Female

271 (19)

909 (16)

163 (18)

Race, n (%)

   

 Asian

36 (3)

100 (2)

11 (1)

 Black

508 (35)

2,456 (43)

438 (49)

 White

802 (55)

2,752 (48)

376 (42)

 Mixed race or other race

52 (4)

196 (3)

40 (5)

 Unknown

52 (4)

187 (3)

31 (4)

Ethnicity, n (%)

   

 Hispanic

376 (26)

1,368 (24)

148 (17)

 Not Hispanic

1,014 (70)

4,138 (73)

723 (81)

 Unknown

60 (4)

185 (3)

25 (3)

Geographic Region, n (%)

   

 US Midwest

25 (2)

259 (5)

35 (4)

 US Northeast

91 (6)

602 (11)

116 (13)

 US South

778 (54)

3,901 (69)

665 (74)

 US West

555 (38)

892 (16)

74 (8)

 US Territories

≤ 5d

37 (1)

6 (1)

Payer, n (%)

   

 Medicare

154 (11)

441 (8)

90 (10)

 Medicaid

355 (25)

1,242 (22)

161 (18)

 Commercial Insurance

761 (53)

2,685 (47)

384 (43)

 Ryan White / ADAP

469 (32)

1,879 (33)

304 (34)

 Cash

11 (1)

66 (1)

≤ 5d

 No payer data available

87 (6)

501 (9)

109 (12)

Core agent class of regimen immediately prior to baseline, n (%)

   

 INSTI

1,062 (73)

2,522 (44)

117 (13)

 NNRTI

127 (9)

823 (15)

52 (6)

 PI

57 (4)

421 (7)

57 (6)

 Entry inhibitor

≤ 5d

≤ 5d

0 (0)

 Unknown

99 (7)

1,718 (30)

635 (71)

 > 1 core agent

104 (7)

203 (4)

35 (4)

CD4 cell count (cells/µL)

   

 CD4 count test result available

1,442 (99)

5,603 (99)

878 (98)

 Median cells/µL (IQR)

730 (550, 944)

675 (484, 892)

678 (471, 861)

Any comorbiditiese, n (%)

1,126 (78)

4,054 (71)

548 (61)

  1. 3DR, 3-drug regimen; 3TC, lamivudine; ART, antiretroviral therapy; BIC, bictegravir; DTG, dolutegravir; FTC, emtricitabine; IQR, interquartile range; INSTI, Integrase strand transfer inhibitor; N, number; NNRTI, Non-nucleoside reverse transcriptase inhibitor; PI, Protease inhibitor; PWH, people with HIV; TAF, tenofovir alafenamide; µL, microliter; US, United States
  2. a DTG/3TC: dolutegravir/lamivudine single-tablet 2-drug regimen
  3. b BIC/FTC/TAF; bictegravir/emtricitabine/tenofovir alafenamide
  4. c DTG 3DR: dolutegravir/abacavir/lamivudine, dolutegravir + tenofovir disoproxil/emtricitabine, or dolutegravir + tenofovir alafenamide/emtricitabine 3-drug regimen
  5. d HIPAA privacy requirements preclude the reporting of 5 or fewer observations in any cell
  6. e Any diagnosis at or prior to baseline of autoimmune disease, cardiovascular disease, invasive cancers, endocrine disorders, mental health disorders, liver disease, bone disorders, peripheral neuropathy, renal disease, hypertension, or substance abuse