Articles
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Citation: AIDS Research and Therapy 2025 22:1
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Myelopathy as the first manifestation of AIDS
Human immunodeficiency virus (HIV) is a retrovirus mainly infecting immune cells. Central nervous system diseases in HIV-infected patients can be caused by HIV or opportunistic infections. Neurological disease...
Citation: AIDS Research and Therapy 2024 21:102 -
Extensive cervical lesion and treatment outcomes in women with HIV/HPV co-infection
Cervical cancer is a common cancer worldwide, with > 85% of deaths occurring in Lower- and Middle-Income Countries where resources for screening programs are limited. Women living with HIV (WLHIV) are at incre...
Citation: AIDS Research and Therapy 2024 21:101 -
Factors associated with oxidative stress in virologically suppressed people living with HIV on long-term antiretroviral therapy
Oxidative stress (OS) is the imbalance between oxidant and antioxidant molecules, in favour of oxidants, that has been associated with an increased risk of morbidity and mortality in ART-treated people living ...
Citation: AIDS Research and Therapy 2024 21:100 -
Differences in people living with HIV (PLWH) population aged over 50 years old receiving antiretroviral therapy (ART)
To explore differences among the elderly people (aged over 50 years old) living with HIV (PLWH) who are receiving antiretroviral therapy (ART), we collected and analyzed data using cross-sectional research met...
Citation: AIDS Research and Therapy 2024 21:99 -
Brief communication: Long-term treatment outcomes of transitioning to dolutegravir-based ART from efavirenz in HIV study participants in Mbeya, Tanzania
The World Health Organization recommends dolutegravir-based antiretroviral therapy (ART) as the preferred first-line regimen for HIV treatment. This retrospective cohort study evaluated the long-term virologic...
Citation: AIDS Research and Therapy 2024 21:98 -
Factor structure of the HIV-SM LMIC self-management questionnaire for people living with HIV in low- and middle-income countries
Despite the need for reliable questionnaires to monitor self-management in chronic disease patients, such tools are lacking in developing countries. This study aims to pilot and assess the construct validity o...
Citation: AIDS Research and Therapy 2024 21:97 -
Effectiveness of dolutegravir-based regimens compared to raltegravir-, elvitegravir-, bictegravir, and darunavir-based regimens among older adults with HIV in the Veterans Aging Cohort Study (VACS)
Real-world data on treatment patterns and clinical outcomes for newer drugs, including integrase strand transfer inhibitors, among older people with human immunodeficiency virus (PWH) are limited.
Citation: AIDS Research and Therapy 2024 21:96 -
Brief Communication: Factors associated with willingness to use long-acting injectable Cabotegravir for HIV pre-exposure prophylaxis (PrEP) among female undergraduate students at a Ugandan university
We assessed the willingness of female students at a Ugandan public university to use long-acting Cabotegravir (CAB-LA) for HIV prevention, given their high prevalence of HIV risk behaviours.
Citation: AIDS Research and Therapy 2024 21:95 -
The effect of emotional freedom techniques on anxiety depression and sleep in older people living with HIV: a randomized controlled trial
To investigate the effect of Emotional Freedom Techniques on anxiety, depression and sleep in older people living with HIV (PLWH).
Citation: AIDS Research and Therapy 2024 21:94 -
Effect of a multimodal continuing professional development initiative on HIV testing in primary care in British Columbia, Canada
Many persons are unaware of HIV infection until they present in an advanced stage of the disease. Diagnosing HIV infection in its earliest stages reduces morbidity and mortality and contributes to improved pub...
Citation: AIDS Research and Therapy 2024 21:93 -
Incidence and risk factors regarding atherosclerotic cardiovascular disease in middle-aged and elderly people with HIV treated in Chongqing, China
Atherosclerotic cardiovascular disease (ASCVD) has become an increasingly common cause of death among people living with HIV (PLHIV) receiving successful antiretroviral therapy (ART). In Chongqing, approximate...
Citation: AIDS Research and Therapy 2024 21:92 -
Case management strategy enhances virological response in people living with human immunodeficiency virus in a resource-limited region in Southwest China: a real-world prospective observational study
This study assessed the effectiveness of case management compared to that of standard care in improving treatment outcomes for first-time antiretroviral therapy (ART) patients in Liangshan Prefecture, China. F...
Citation: AIDS Research and Therapy 2024 21:91 -
Cumulative incidence and treatment effectiveness of low bone mineral density among people living with HIV in Iran (2021–2023)
The introduction of antiretroviral therapy (ART) has significantly improved the life expectancy of people living with HIV (PLHIV), leading to an increased prevalence of age-related comorbidities such as osteop...
Citation: AIDS Research and Therapy 2024 21:90 -
TheU-shape association between on-admission resting heart rate and 60-day all-cause mortality of AIDS inpatients in Fujian China: a retrospective cohort study
An elevated resting heart rate (RHR) is associated with poor outcomes in both healthy individuals and those with human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS). This study aime...
Citation: AIDS Research and Therapy 2024 21:89 -
HIV-associated neurocognitive disorders in Africa: challenges, peculiarities, and future directions
The impact of Human Immunodeficiency Virus (HIV) on neurocognition in Africa is a pressing public health issue, with profound implications for both individual well-being and healthcare systems across the conti...
Citation: AIDS Research and Therapy 2024 21:88 -
Ixekizumab: an alternative for HIV-positive psoriasis patients
Psoriasis is a recurrent and protracted inflammatory disease. Generalized erythema, plaques, and silvery scales on the surface mainly characterize its skin lesions. Biologics bring new hope to psoriasis patien...
Citation: AIDS Research and Therapy 2024 21:87 -
Brief communication: efficacy and safety of the dolutegravir/lamivudine dual therapy in antiretroviral treatment-experienced Chinese people living with HIV
This study aimed to evaluate the efficacy and safety of dolutegravir plus lamivudine (DTG/3TC) in antiretroviral treatment (ART)-experienced people living with HIV (PLWH). A total of 303 PLWH in Shanghai, Chin...
Citation: AIDS Research and Therapy 2024 21:86 -
Compliance with reporting standards in Mobile App interventions for ART Adherence among PLHIV
In recent decades, there has been a proliferation of mobile health (mHealth) interventions to address public health challenges such as HIV/AIDS. Hence, there is a need for standardizing the report of mHealth i...
Citation: AIDS Research and Therapy 2024 21:85 -
Traditional complementary and alternative medicine (TCAM) use among PLHIV on antiretroviral medication
Traditional complementary and alternative medicine (TCAM) are products and practices that differ from conventional allopathic medicine. There continues to be an increase in the use of these methods of treatmen...
Citation: AIDS Research and Therapy 2024 21:84 -
Clustering affordable care act qualified health plans to understand how and where insurance facilitates or impedes access to HIV prevention
With access to and uptake of pre-exposure prophylaxis (PrEP), the United States can prevent new HIV infections. To end the HIV epidemic, health insurance plans must facilitate access to comprehensive preventiv...
Citation: AIDS Research and Therapy 2024 21:83 -
Prevalence, associated factors, barriers and facilitators for oral HIV self-testing among partners of pregnant women attending antenatal care clinics in Wakiso, Uganda
Oral HIV self-testing (HIVST) among men is relatively low and still inadequate in Sub-Saharan Africa. Delivering HIVST kits by pregnant women attending antenatal care to their partners is a promising strategy ...
Citation: AIDS Research and Therapy 2024 21:82 -
The role of CREB and MAPK signaling pathways in ATLL patients
HTLV-1 is a worldwide distribution retrovirus with 10–20 million infected individuals. ATLL is an Adult T-cell leukaemia lymphoma caused by aggressive T-cell proliferation that is infected by HTLV-1 and is ass...
Citation: AIDS Research and Therapy 2024 21:81 -
AIDS mortality in Brazil, 2012–2022: a time series study
Human immunodeficiency virus (HIV) infection is a health problem in Brazil and worldwide. Without treatment, the infection can progress to Acquired Immunodeficiency Syndrome (AIDS), with a high mortality poten...
Citation: AIDS Research and Therapy 2024 21:80 -
Association between differentiated HIV care delivery model and low-level viremia among people living with HIV in Rwanda
Low-level viremia (LLV) (HIV-RNA 51–999 copies/mL) is associated with increased risk of non viral load suppression (HIV-RNA ≥ 1000 copies/mL). We assessed the association between differentiated service deliver...
Citation: AIDS Research and Therapy 2024 21:79 -
Brief communication: The cohort of women prescribed HIV PrEP at the Veterans Health Administration
The goal of this study was to describe the cohort of women prescribed PrEP at the Veterans Health Administration. We used a cross-sectional study of electronic health record data. We used descriptive statistic...
Citation: AIDS Research and Therapy 2024 21:78 -
Brief communication: comorbidities and aging in people living with HIV
The main objective of the study was to assess the occurrence of non-aids-related comorbidities typical of aging in people living with HIV diagnosis 20 years ago or more and under treatment with antiretroviral ...
Citation: AIDS Research and Therapy 2024 21:77 -
Virologically suppressed switch to Dolutegravir/Lamivudine 2-Drug regimen versus switch to commonly prescribed 3-Drug regimens in the United States
Two-drug regimens (2DRs) have been introduced in recent years to potentially reduce antiretroviral therapy (ART) toxicities and drug-drug interactions while demonstrating comparable efficacy to three-drug regi...
Citation: AIDS Research and Therapy 2024 21:76 -
Brief communication: Effect of mobile health intervention on medication time adherence among people living with HIV/AIDS receiving care at selected hospitals in Owerri, Imo State Nigeria
This study aimed to assess the impact of Mobile health (M-health) on medication time adherence among people living with HIV/AIDS (PLWHA).
Citation: AIDS Research and Therapy 2024 21:75 -
Brief communication: The extent and determinants of viral suppression among patients on protease inhibitor-based Anti-retro-viral therapy undergoing intensive adherence counselling in a public HIV care center in Uganda
Protease inhibitor (PI)-based Antiretroviral Therapy (ART) regimens are key drugs in HIV management, especially when used as second line drugs. However, some PI-based ART have high adherence demands or tolerab...
Citation: AIDS Research and Therapy 2024 21:74 -
Mucosal leishmaniasis of the lips and cheeks: a first concomitant presentation of visceral and mucosal leishmaniasis in a patient living with HIV/AIDS in Monastir, Tunisia
Visceral Leishmaniasis (VL) is the most severe and fatal disease if left untreated. In people living with HIV/AIDS (PLHA), VL is considered an emerging opportunistic infection. The aim of this manuscript was t...
Citation: AIDS Research and Therapy 2024 21:73 -
Brief communication: coagulation profiles of HIV positive patients on antiretroviral therapy (ART) at the Mampong Municipal Hospital, Ashanti-Region, Ghana: a case control study
This study aimed to ascertain how the current two ART regimens used in Ghana affected HIV patients’ coagulation profiles. A case-control study was conducted on 102 HIV positive patients at the Mampong Municipa...
Citation: AIDS Research and Therapy 2024 21:72 -
Epidemic of multiple Treponema pallidum strains in men who have sex with men in Japan: efficient multi-locus sequence typing scheme and indicator biomarkers
The challenges in culturing Treponema pallidum have hindered molecular-biological analysis. This study aims to establish a molecular epidemiological analysis of syphilis among Japanese men who have sex with me...
Citation: AIDS Research and Therapy 2024 21:71 -
Uptake of early infant HIV diagnosis and its associated factors in Tanzania: an analytical cross-sectional study
The uptake of early infant HIV diagnosis services is crucial for preventing mother to child transmission of virus, and timely management. However, the uptake of the services remains a global challenge, despite...
Citation: AIDS Research and Therapy 2024 21:70 -
Missed opportunity: low awareness of undetectable equals untransmittable (U = U) among adolescents living with HIV
In 2022, South Africa (SA) had the second-highest HIV incidence rate among adolescents worldwide. This study’s participants were boys living in SA aged 15–19 years old, in a current dating or sexual relationsh...
Citation: AIDS Research and Therapy 2024 21:69 -
Association of ART regimen and adherence to viral suppression: an observational study of a clinical population of people with HIV
Adherence to antiretroviral therapy (ART) is essential for the effective management of HIV, which includes keeping the HIV viral load undetectable. This study aimed to determine whether certain ART medications...
Citation: AIDS Research and Therapy 2024 21:68 -
A matters arising: a structural equation modeling approach to investigate HIV testing willingness for men who have sex with men
This is a Matters Arising about an article titled “A structural equation modeling approach to investigate HIV testing willingness for men who have sex with men in China” in the issue of AIDS Res Ther 20, 64 (2...
Citation: AIDS Research and Therapy 2024 21:67 -
Safety of different amphotericin B formulations among AIDS patients with invasive fungal disease: a retrospective observational study
We conducted a retrospective, observational study among acquired immune deficiency syndrome (AIDS) patients with cryptococcal meningitis or talaromycosis to assess AmB formulations-related adverse events (AEs)...
Citation: AIDS Research and Therapy 2024 21:66 -
Public health response to Mpox: Safeguarding vulnerable Key Populations and People Living with HIV in Zanzibar
Mpox, caused by the Monkeypox virus (MPXV), has emerged as a significant global public health concern, particularly affecting vulnerable populations. The recent outbreak in the Democratic Republic of the Congo...
Citation: AIDS Research and Therapy 2024 21:65 -
Correction: Adverse events of inactivated COVID-19 vaccine in HIV-infected adults
Citation: AIDS Research and Therapy 2024 21:64 -
Correction: Immune response and safety to inactivated COVID-19 vaccine: a comparison between people living with HIV and HIV-naive individuals
Citation: AIDS Research and Therapy 2024 21:63 -
HIV drug resistance: analysis of viral genotypes and mutation loci in people living with HIV in Chongqing, China (2016–2023)
Large-scale HIV genotype drug resistance study has not been conducted in Chongqing.
Citation: AIDS Research and Therapy 2024 21:62 -
Correction: Facilitators and barriers to initiating and completing tuberculosis preventive treatment among children and adolescents living with HIV in Uganda: a qualitative study of adolescents, caretakers and health workers
Citation: AIDS Research and Therapy 2024 21:61 -
Motivation, responsibilities, and experiences of HIV/AIDS counselors in the Volta Region of Ghana: a descriptive phenomenological study
The provision of professional counseling services for persons living with human immunodeficiency virus (PLHIV) is crucial in the prevention and treatment continuum of the disease. However, for counselors of pe...
Citation: AIDS Research and Therapy 2024 21:60 -
Facilitators and barriers to initiating and completing tuberculosis preventive treatment among children and adolescents living with HIV in Uganda: a qualitative study of adolescents, caretakers and health workers
People living with HIV (PLHIV) have a 20-fold risk of tuberculosis (TB) disease compared to HIV-negative people. In 2021, the uptake of TB preventive treatment among the children and adolescents living with HI...
Citation: AIDS Research and Therapy 2024 21:59 -
Determinants of survival time for HIV/AIDS patients in the pastoralist region of Borena: a study at Yabelo General Hospital, South East Ethiopia
HIV/AIDS is one of the most dangerous diseases globally, impacting public health, economics, society, political issues, and communities. As of 2023, the World Health Organization estimates that 40.4 million pe...
Citation: AIDS Research and Therapy 2024 21:58 -
Kidney transplant recipient with history of HIV, HBV, and past HCV infection
Chronic viral infections caused by the human immunodeficiency virus (HIV), hepatitis C (HCV), and hepatitis B (HBV) are common among patients with end-stage renal disease (ESKD). These infections were once con...
Citation: AIDS Research and Therapy 2024 21:57 -
Level of knowledge and intention to use oral fluid HIV self-testing and associated factors among Ethiopian health care workers in southern Ethiopia
The World Health Organization has recommended a new method for HIV self-testing (HIVST) using oral fluid, intending to increase HIV testing rates, and linking individuals to medical care. Healthcare workers ar...
Citation: AIDS Research and Therapy 2024 21:56 -
Optimization of the vertical transmission prevention program in Guinea: impact of the improvement plan on performance indicators at large-cohort sites
Vertical transmission of HIV remains a major challenge in Guinea, especially, in low-resource rural areas. This paper presents the results of a pilot project designed to enhance the prevention of vertical tran...
Citation: AIDS Research and Therapy 2024 21:55 -
Use and non-adherence to antiretroviral therapy among Refugee HIV positive pregnant mothers aged 18–49 years in Kyangwali refugee camp, Western Uganda
Refugee HIV positive mothers experience significant obstacles in accessing, utilizing and adhering to antiretroviral therapy (ART). Identifying ART non-adherence can help in the development of interventions ai...
Citation: AIDS Research and Therapy 2024 21:54